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  2 0 The "research" at the link was not particularly helpful in answering this or any other question. Cannabis has been around for thousands of years, and there is much research over the centuries. In my opinion, the book "Marijuana Potency" by Starks covers these topics thoroughly. Sativa tends to have more THC, and is uplifting. Indica tends to have more CBD and CBN, and has more of an alcohol-type effect. Kevin answered in 420: The Straight Dope About Pot over 2 years ago | Report 2 comments by stumbletown and Kevin… 0 0 No need to be dismissive of the research. If you have a problem with the methodology or don't understand the write up, then explain so, instead of passive aggressively use quotes to discredit it. While you might not think it helpful in answering mine or any other question, better understanding of the different roles of cannibinoids could have very practical implications for both new applications of medical cannabis and allowing a wider range of people to benefit from it. I do appreciate the input though, and look forward to picking up a copy of Starks work. Also I would recommend reading Michelle Sexton's response below, it was very informative & interesting. stumbletown commented over 2 years ago | Report 0 0 Yes, my remark was too generalized. What I object to in particular is the idea that pot causes psychiatric problems, as implied in the statement at the end about the etiology of psychiatric problems. "etiology" means the cause or origin. LSD can trigger psychiatric symptoms, if there were underlying potential. Pot can hinder neurological development if taken before the brain is mature. Though if taken by adults, pot preserves the brain and serves overall health. As far as measuring disinhibition, that is a tricky question. In some ways pot may inhibit, in other ways it may disinhibit. Also I doubt the researchers isolated the THC from the other compounds of natural cannabis. Kevin commented over 2 years ago | Report Enter your comment or ask a new question New comments are not being accepted at this time.

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  2 0 There is quite a bit of "bench" research going on in the U.S. and a few clinical studies in Europe where various combinations of the two primary cannabinoids in Cannabis (standardized in whole plant extracts) are being performed. We learn some about specific mechanisms of action by separating the compounds and doing cell culture or even in vivo experiments, but there is obviously quite a lot of synergy going on between all of the 60-80 Cannabinoids, flavonoids, phenolic compounds etc. . . ! Scientists have not perfected experiments on plant synergy, we are so used to reductionistic science, but there appears to be the largest uncontrolled trial in history occurring with humans using Cannabis for a variety of conditions, and no one knows the ratios of the most active compounds. CBD attenuates the psychotropic effects of THC (perhaps explaining why some patients did not 'like' Marinol), and is also anti-inflammatory, although not through the classic Cannabinoid receptors that are commonly studied. But you are right. . . it would be great to know more, and it is unfortunate that Cannabis has mostly been exploited and bred for high THC content. THC does have a primary role, no doubt (in anesthesia, analgesia) yet the plant's own wisdom is probably the best rule! Michelle Sexton ND Senior Postdoctoral Fellow, University of Washington Cannabis researcher Michelle Sexton answered in 420: The Straight Dope About Pot over 2 years ago | Report 1 comment by Hempstead,NY… 0 0 There are things about which one should be conservative, I think. One of those is any plant's drugs profile when it has been bred by humans for thousands of years (hundreds of years only, though, if we're talking about smoking). With better psychopharmalogic knowledge and understanding of plant genetics, I'm sure we could improve on what we and Nature have arranged, but until then I wish it were possible to find (say) traditional Thai and Lao strains that haven't had their THC content amped to Hell and back. Hempstead,NY commented over 2 years ago | Report Enter your comment or ask a new question New comments are not being accepted at this time.

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  0 0 Beyond my reach, but thanks for the link. Interesting findings. normstamper answered in 420: The Straight Dope About Pot over 2 years ago | Report Comment on this answer Enter your comment or ask a new question New comments are not being accepted at this time.

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