Since you stipulated that you were a gay couple, you'll be glad to know that Van is a very tolerant city. Very tolerate. The mecca, of course, in Van is the Davie Village. That's on Davie Street between, say, Hornby and Denman. Wild-ass clubs but also tasteful little bistros - something for everybody.

Granville Island is great, but it'll be packed this weekend - especially if the weather's not co-operative for outdoor activities. Like to shop? West 4th across the Burrard Bridge from downtown and in Kitsilano has a wide array of great shops. Nice restaurants, too. Granville Street is a lot of fun, I think. Speaking of restaurants, if you like real, fresh fish and chips, there's Mr. Pickwick's on Denman. For a seafood dinner that everyone raves about, there's the Fish House in Stanley Park. The Saturday or Sunday brunch (10 to 3, I think) at the Teahouse in Stanley Park is exquisite. As is the dining experience at Rain City Grill (a local favorite) on Denman. The Fish House, Teahouse, and RCQ are a bit upscale. Mr. Pickwick's is casual.

Frankly, there is so much fun in Vancouver that I'd save the museums and the art galleries for the 2nd trip. Oh yes...there will be one. Or check them out on Sunday since you'll be there all day. Do that walking tour that Fnarf has suggested. It's a winner!

You're going to love it!

Granville Island for sure. In the public market, I would recommend Oyama Sausage Co: buy some paté, some duck prosciutto or whatever else catches your eye (you can get bread from nearby Terra Breads to eat with it). Taking the water taxi to/from there can be fun.

Dimsum, I think is better than Seattle's. In Vancouver, I'd suggest Kirin Restaurant, they have a few different locations and its consistently good. Fisherman's Terrace (in Richmond) does good dimsum if you're out there (the new skytrain 'Canada line' makes it really easy now).
If you're interested in xiao long bao, I'm a big fan of Dinesty (also in Richmond).

Stanley Park is nice for the views and has the Vancouver Aquarium (Beluga whales!); there's a handful of bike rental places around Denman/Robson if you'd rather bike along the seawall instead of walking. There's some good izakayas (Japanese pubs) there too.

other restaurant recommendations: Japadog, Market, La Brasserie, Chambar/Medina, Vij's/Rangoli, Salade de Fruits, Maenam, Salt Tasting Room, Boneta...

Well, there's always the museum of art right downtown... And if the admission price is too steep, just walk into their gift shop, and walk around. You'll see reproductions of many of the works of art that are on display inside, for free!

There's a suspension bridge a little bit north of Vancouver where you park on one side and then walk across to an old growth stand of beautiful big pine trees with a boardwalk, informational displays, craftmen and interpreters. It's good for a couple of hours, but frequently wet and cloudy.

There's an overlook for the main bridge across the harbor that's got a spectacular view. And if you go down on the island, you can drive around the permiter, park and get a horse drawn carriage ridge that will tell you the history of the park. There's lots of first nation totem poles there as well.

Over in gastown, there's a steam driven clock that plays every hour... with lots of shops, etc. If it's still open, Storium was a live theatre in the round exhibit in gastown that presented the history of British Columbia and was outstandingly good!

Granville Island was only so-so, as I recall, but as a trendy destination for eating and shoping, it's OK.

And there's some very nice upscale resturants down by the convention center where the Olmpics broadcast/journalism center was built. You can always walk around the pier and plaza area and meet the street vendors and people watch down there.

Seems to me we saw some handbills there on light poles promoting a few gay bars, or showbills for strip joints or nude photo exhibits in the greater area... but never had the time to hunt them up.

One caution: There's a LARGE homeless population of panhandlers and street people in downtown Vancouver, BC... like any major metropolitan area these days. Beware and keep yourself safe and secure. Make sure your wallet or purse is safe at all times! (Never had a problem, but it's an apparant problem.)

Granville Island is always fun. It's sorta like the Pike Place Market of Vancouver.

We have friends who live a few blocks off Commercial Drive, and that's always fun to just wander through. There's a great Cuban restaurant there called Havanas (1212 Commercial). Great fried chicken, pitchers of mojitos.

Also, look up La Casa Gelato. It's a gelato place that has, seriously, about 300 flavors. Everything from chocolate to Guinness to lavender to durian. Good times.