Distilling is often one of those things that is better done on a large scale than a smaller scale. It's sad because I want to support the little guy, but with something like bourbon or other aged distilled alcohol, the big guys just have an advantage.
Think about it. Almost all Bourbon is aged 2 years. Most decent stuff is aged a minimum of 4. And the best stuff has nothing in it younger than 6 years. This means that if I started distilling tomorrow and wanted to compete with the big boys, I have to wait 6 years before I have any product to sell. This pushes me to start releasing stuff earlier rather than later. So I release 1/2 my stuff at 2 years, 1/2 of what's left at 4, 1/2 what's left at 6, and the rest at 8. This also means that my supply is artificially low. To make this up I'm probably bottling at 80 proof so I can sell more bottles, whereas a lot of brand are bottling at a much higher proof. On top of all this because my supply is so low and the demand is fairly high (whether deserved or not) my price is going to be fairly high. Even if my quality is just as good as something like Buffalo Trace my price is going to be much, much higher. For example, Buffalo Trace can be bought in the state for $28. The state store is currently selling Hudson 4-Grain Bourbon from a micro distillery in New York for $50 for a 375ml bottle. I've had both, and can say while it's well made; it's not as good. And it's certainly not worth almost 4x the price.
With the big brands you also have the advantage of years and years of knowledge (and with it illegal to distill at home, it's hard to catch up quick). How do you decided on your mash bill percentages? Even a 1% shift from corn to rye can actually make a difference. You figure it out by experimenting, but if it takes a minimum of 2 years to do the experiment you are in a tough place. That's not even mentioning the kind of oak you are using, the level of char, temperature and conditions of aging, what proof you are aging at, etc.
With tons of raw material they also have the ability to blend from different barrels (even of different ages) to make a consistent tasting product. Your small distillery might make a great Bourbon one year, and a so so one the next simply because one or two of their barrels were slightly flawed. Even if I'm going to make 1000 cases of finished product, I'm only using 45 barrels of alcohol. If something goes wrong with one or two of them, I either have to eat the cost or try to blend it in and accept the consequences.
To make matters worse, the distilling industry wasn't caught flat footed like a lot of the large wineries and breweries were. Almost all of them are creating small batch, distinct, very old, experimental, or other specialty bottlings of their products. One of the reasons that micro brewed beer took off was that all the big breweries were basically producing similar stuff. There are probably an equivalent number of big distilleries as there were big brewers. However, look at the variety that even someone like the Sazerac company makes; they cover just about all your American whiskey bases.
If the micro distillers are to succeed. They're really going to have to differentiate themselves from most American Whiskey. That may mean getting very experimental and doing things like 100% corn Bourbon. Or making Scotch or Irish style Whiskey. Or aging for a minimum time in new oak, but aging longer in used wine barrels. All of that is a pretty big and expensive gamble. Which is why you see the majority of the products coming out are white dog whiskey, vodka, gin, and eau-de-vie.