Per my comment to Fnarf... Bailo and Fnarf are correct about large currency transactions being reported (those greater than $10,000 - an even $10,000 itself is below the threshhold, but $10,001 gets a report filed with the feds). But you don't want to do anything to avoid the report. If you do and it gets noticed (and it will be noticed - don't think it won't be), then another reported, called the Suspicious Activity Report (SAR), is filed with the feds.
The purpose of these reports is to track possible money laundering. A one-time deposit of all that cash might raise eyebrows at the bank, but if you go to a high-traffic branch of a major bank, chances are someone there has seen it before and won't automatically believe you're doing something illegal. It'll help if you're well groomed; if you look like a tweaker, they may file a SAR anyway.
You could, I suppose, go to a bunch of different banks, but they'd all have to be unique institutions. If you deposit at different branches of the same bank, the reports will find you out.
As Bailo notes, there's nothing illegal about having that much cash, and nothing illegal about depositing it, as long as it was legally acquired. You probably won't get too much attention if you do this just one time, and never again. All the big banks see large cash deposits and withdrawals every day, and it's the pattern of repeatedly doing this, especially with no reasonable explanation for it, that's gets attention. BUT.... if I were you, I'd be ready to tell the truth about how I came into such a large sum, and have any supporting documentation ready to present. Because you never know.