I listen to podcasts all day at work, here is my current list:
(note: not all of these are listened to regularly but are good to have some backup if some of the standbys don't update when you expect them to)
APM: The Splendid Table - cooking show
As It happens - canadian news commentary
Jordan, Jesse, Go! - people talking about random topics
Leo Laporte - the Tech Guy - nerdy
The Moth - amazing stories
MSNBC Rachael Maddow Show - you can get the full epp for free!
Car Talk - ammusing from time to time
Wait Wait don't tell me - good monday mornings
On the Media - NPR news show
PRI: The Sound of Young America - interesting interviews
To the Best of our Knowledge - more NPR goodness
Savage Love Podcast - some guy talking about sex.
The Sporkful - conversations about food.
Stack of Dimes - Local people talking about random topics
This American Life - hipster's wet dream.
Too beautiful to Live - used to be a radio show, now it's a podcast, local.
Travel with Rick Steves - rarely listened to, but interesting from time to time.
Wiretap - canadian radio at its best.