Doug Loves Movies is one of my favorites. It's Doug Benson and 2-3 guests (usually other somewhat well known comedians but sometimes actors/directors) talking about movies and playing games.
NPR's planet money podcast is decent.
You can get previous episodes of This American Life to take with you, as well as Wait Wait Don't Tell Me.
I'll throw one out for Sklarbro Country, which is theoretically about sports (they cover a lot of ground) but the Sklar Bros. are so hilarious it's worth it even if you're not into the subject matter.
KCRW's morning becomes eclectic has some good live performances.
Chris Hardwick hosts the Nerdist podcast, which can be kind of hit and miss, depending on the guest.
Finally, Kevin Pollak's Chat Show for the long-form interview. Those are available in both audio and video format.