My mother-in-law lived there, so we visited a few times. Tucson has awesome thrift shopping, because old people move there with all their finery and winter clothes and then just live in Tommy Bahama. Seriously, minks and cashmere and good mens suits. I can't recall the name of the neighborhood with all the vintage shops, but if you ask around and find it, there are fun bars and restaurants around there. I don't recall any microbrews, but Google says there are some, so there you go.
The Arizona Desert Interpretive Museum is fun, and an medium/easy walk for seniors/olds. A great way to see and learn about the flora and fauna of the desert. You may just see a javelina - they smell terrible. The folks here would be good people to ask about hikes - where to go and what to bring with you.
Mission San Xavier de Bac is a 200+ year old Spanish mission church out on the 19. It's in the process of being restored, so check to see if it's open the public. We went one year at Christmas and it was very beautiful and with an interesting (colonial, troubling) history. It is an active mission for the Tohono O'odham people, so be respectful. You can buy frybread and Indian crafts in the parking lot.
http://www.sanxaviermission.org/